The reversal effects of recombinant human augmenter of liver regeneration to immunocomplex induced liver fibrosis
- VernacularTitle:重组人肝再生增强因子可逆转免疫损伤性肝纤维化
- Author:
Aimin WANG
;
Shuangcun DU
;
Xiaoming YANG
;
Ruifeng GUO
;
Qingming WANG
;
Fuchu HE
- Publication Type:Journal Article
- Keywords:
Recombinant proteins;
Immunostimulating complexes;
Liver diseases
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the anti-fibrosis activity of recombinant human augmenter of liver regeneration (hALR). METHODS: Albumin induced rat model of liver fibrosis was established and hALR was given peritoneally after the model production. Serum concentration of alanine aminotransferase(ALT), aspartic aminotransferase(AST), lactate dehydrogenase(LDH), hepatic collagen contents and pathological examination were selected as observing parameter. RESULTS: Recombinant human augmenter of liver regeneration (hALR) could decrease ALT, AST, LDH concentration of fibrotic rats. The measurements of hepatic collagen contents showed that hepatic collagen contents in hALR treatment group was much lower than those of model group and negative control group. Pathological examination also indicated that the degree of liver fibrosis in hALR treatment group was attenuated in comparison with those of model group and negative control group. CONCLUSION: Recombinant human augmenter of liver regeneration (hALR) had reversal effects on immunocomplex induced rat liver fibrosis.
