Effects of electrical stimulation of ventral septal area on discharge of pyrogen-treated thermosensitive neurons in preoptic anterior hypothalamus region of rabbits
- VernacularTitle:电刺激VSA对IL-1_?作用下兔POAH温敏神经元放电的影响
- Author:
Jun DONG
;
Chujie LI
;
Daxiang LU
;
Yongmei FU
;
Liang YAN
- Publication Type:Journal Article
- Keywords:
Septal nuclei;
Preoptic area;
Anterior hypothalamic area;
Body themperature regulation;
Interleukin - l;
Electrophysiology
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: To investigate the effect of electrical stimulation of ventlal septal area (VSA) on discharge of pyrogen - treated thermosensitive neurons in preoptic anterior hypothalamus (POAH) region, the discharging rate of thermosensitive neurons in the POAH region of 32 New Zealand white rabbits were recorded by using extracellular microelectrode techinque. RESULTS: (1) Intraceretroventricularly (i c v) injection of interleukin - 1?(IL - 1?) caused decrease of discharging rate of warm - sensitive neurons and increased in discharging rate of cold - sensitive neurons in POAH regions. (2) These effects could be reversed by electrical stimulation of VSA. CONCLUSION: VSA may play a central role of negative regulation in thermoregulation of pyrogen - treated animal.
