The relations among PAMP, ADM and Ang Ⅱ on vascular tissue
- VernacularTitle:PAMP、ADM和AngⅡ在血管组织释放的相互影响
- Author:
Jian MA
;
Zaiquan LI
;
Chaoshu TANG
;
Ye YANG
- Publication Type:Journal Article
- Keywords:
Angiotensin Ⅱ;
Radioimmunoassay;
Rats;
Aorta
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To elucidate the relations among proadrenomedullin N terminal 20 peptide (PAMP), adrenomedullin(ADM) and angiotensin Ⅱ (Ang Ⅱ). METHODS: Tissue slices of rat aorta were incubated as follows: (I) increasing concentrations of Ang Ⅱ (10-9, 10-8, 10-) mol/L); (Ⅱ) increasing concentrations of PAMP(10-9, 10-8, 10-)mol/L). The tissue and incubation concentrations of PAMP, ADM and Ang Ⅱ were measured by the radioimmunoassay (RIA). RESULTS: The tissue and incubation concentrations of PAMP and ADM were concentration - dependently increased by Ang Ⅱ, but the tissue and incubation concentrations of Ang Ⅱ can not effected by PAMP. CONCLUSION: AngⅡ markedly stimulate the release of ADM and PAMP. It may be one of the factors which regu- late the synthesis and release of ADM and PAMP. The regulation may play an important role in homastasis regulation of cardiovascular system.
