Effect of poly(ADP - ribose) polymerase on the response of guinea pig tracheas induced by peroxynitrite in vitro
- VernacularTitle:多聚(二磷酸腺苷-核糖)聚合酶介导过氧亚硝基阴离子致豚鼠气道反应性增高的研究
- Author:
Tienian ZHU
;
Yiling LING
;
Ruijing ZHAO
;
Zhenyong GU
;
Manying LIU
- Publication Type:Journal Article
- Keywords:
Poly a polymerase;
Anions;
Airway resistance
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: to elucidater the effect of poly(ADP-ribose) polymerase(PARP) on tracheal hyperreactivity of guinea - pig induced by peroxynitrite, the responses of guinea pig tracheas to histamine af- ter incubation with peroxynitrite in the absence and presence of 3 - aminobenzamide(3 - AB), a highly selective inhibitor for PARP, were observed in vitro. RESULTS: The exposure of tracheal strips to peroxynitrite led to epithelial damage and hyperreacitivity to histamine, both of which were reversed by 3 - AB(l mmol/L or 5mmol/L), whereas incubation of tracheal strips with 3 - AB(5 mmol/L) had no effect on the reponses. CONCLUSION:PARP is involved in the epithelial damage and hyperreactivity of guinea - pig tracheas induced by peroxynitrite. The results suggested that inhibition of excessive activation of PARP may represent a novel strategy for the prevention and therapy of airway hyperreactivity in asthma.
