Fibroblasts function as "sentinel cell" in inflammatory reaction
- VernacularTitle:成纤维细胞在炎症反应中具有“岗哨细胞”的作用
- Author:
Xiaomeng NIE
;
Xiaowen HE
;
Jian LU
- Publication Type:Journal Article
- Keywords:
Fibroblasts;
Inflammation;
Immunity, cellular
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The fibroblasts have long been considered as structural elements and playing a main role in wound healing. Recent studies indicated that fibroblasts are heterogenic cells and function as resident sentinel cells in inflammatory reaction. When activated by substances released during tissue injury or derived from infectious microorganisms or by proinflammatory cytokines, tissuespecific fibroblasts can transiently produce certain chemokines and initiate a cascade of inflammatory reaction. In addition fibroblasts can produce prostanoids that participate in inflammatory and immune responses. In this review, the new role of fibroblasts in regulation of inflammation and immune reactions and possible molecular mechanism will be discuss.
