The function of Hoxa - 10 gene in the reproductive system
- VernacularTitle:Hoxa-10基因在生殖过程中的作用
- Author:
Hong LI
;
Shiling CHEN
;
Fuqi XING
- Publication Type:Journal Article
- Keywords:
Gense, homeo box;
Gene expression;
Reproduction
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Hoxa gene plays an essential role in the generation and development of the human female reproductive system. This gene is expressed in the Mullerian duct and the adult female reproductive system. Expression of Hoxa10 dramatically increased during the midsecretory phase of the menstrual cycle, corresponding to the time of implantation. Female mice lacking Hoxa10 have a uterine factor defect that results in death of the preimplantation embryo and failure of implantation. These results suggest Hoxa10 may have an important function in implantation. Hoxa10 - deficient males exhibit cryptorchidism that lead to male infertility.
