Influnce of gelatins and dextran on fibrinogen and platelet glycoproteinⅡb/Ⅲa
- VernacularTitle:明胶溶液和右旋糖酐对血小板膜糖蛋白受体和纤维蛋白原的影响
- Author:
Yaqun MA
;
Ningling PAN
;
Xianbi PAN
- Publication Type:Journal Article
- Keywords:
Gelatin;
Dextran;
Platelet aggregation;
Platelet membrane glycoprotein GPⅡb/Ⅲa complex;
Fibrinogen
- From:
Chinese Journal of Anesthesiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of gelatins and dextran on fibrinogen and platelet glycoproteinⅡb/Ⅲa (GPⅡb/Ⅲa).Methods One hundred and five patients for selective cholecystectomy were randomly divided into four groups. In groupⅠ normal saline 30ml/kg was infused, in groupⅡ dextran-70 30ml/kg,in groupⅢ urea-linked gelatin 30ml/kg and group Ⅳ modified fluid gelatin 30ml/kg. The blood samples were taken before infusion ,two hours and three hours after the infusion, to measure platelet maximum aggregation rate (MAR), levels of Fbg and GPⅡb/Ⅲa,respectively.Results As compared with those in other groups, MAR and level of GPⅡb/Ⅲa decreased significantly in groupⅡ(P
