The protective effect of preconditioning on rabbit liver during ischemia and reperfusion and its potential mechanism
- VernacularTitle:预处置对急性缺血再灌注肝脏保护机制的初步探讨
- Author:
Wantie WANG
;
Lina LIN
;
Zhengjie XU
;
Dong LI
;
Zhouxi FAN
;
Zhongmin WANG
- Publication Type:Journal Article
- Keywords:
Liver;
Reperfusion injury;
Nitric oxide;
Oxygen;
Free radicals
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the protective effect of preconditioning on rabbit liver during total ischemia and reperfusion and its mechanism. METHODS: Using hepatic ischemia and reperfusion injury (HIRI) model in rabbits, animals were randomly divided into three groups: control group (A), non-preconditioning group(B) and preconditioning group(C), different effects of preconditioning on several parameters including alanine aminotransferase (ALT) activity and levels of nitric oxide (NO) and malondialdehyde (MDA) in plasma or liver tissue as well as hepatocellular morphological changes were measured and observed during HIRI. RESULTS:In C group NO levels of plasma and liver tissue were higher than those in B group (P0.05); abnormal morphological chages of liver cells in A group were ameliorated remarkably too during HIRI. CONCLUSION:Preconditioning can attenuate HIRI by improving NO level and reducing oxygen free radicals level.
