The stimulating effects of neuropeptide Y on cultured arterial smooth muscle cell proliferation and losartan treatment
- VernacularTitle:Losartan对神经肽Y诱导血管平滑肌细胞增殖的逆转作用
- Author:
Shaohua HUANG
;
Jiankang LIU
;
Minsheng CHEN
- Publication Type:Journal Article
- Keywords:
Neuropeptide Y;
\ Angiotensin Ⅱ;
Receptors, angiotensin;
Muscle, smooth, vascular
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe expression of proliferating cell nuclear antigen (PCNA), platelet derived growth factor (PDGF) and c-myc in cultured vascular smooth muscle cells which is effected by neuropeptide Y (NPY) and losartan (the receptor blocking agent of angiotensin Ⅱ) therefore exploring effects of NPY on the generation of hypertension and its relationship with losartan reverse treatment in molecular biology. METHODS: Applied the method of quantitative immunocytochemistry through ACAS570. RESULTS: 24 hours exposure of vascular smooth muscle cell to NPY caused an increase in expression of PCNA, PDGF and c-myc respectively. But losartan could reverse these expressions by NPY, decreased the expression of PCNA, PDGF and c-myc. CONCLUSION: NPY is closely related to the generation of hypertension. But losartan could reverse these effects of NPY.
