Effect of angiotensin Ⅱ on the remodeling of aorta in spontaneously hypertensive rats
- VernacularTitle:血管紧张素Ⅱ在自发性高血压大鼠主动脉重建中的作用
- Author:
Kaihong JI
;
Zonglai JIANG
;
Xiangqun YANG
;
Jianliang ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Blood vessels;
Angiotensin Ⅱ;
Muscle, smooth, vascular;
Cells;
Collagen
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of a 10-weeks treatment with angiotensin Ⅱ (Ang Ⅱ) subtype I receptor antagonist losartan on vascular remodeling of thoracic aorta in male spontaneously hypertensive rats (SHR). METHODS: SHR were treated from 16 to 26 weeks of age with losartan at 15 mg/kg?d -1 or 0.75 mg/kg?d -1. RESULTS: Losartan (15 mg/kg?d -1) treatment significantly decreased systolic blood pressure compared with the control group, while losartan (0.75 mg/kg?d -1) had no the effect, losartan(15 mg) prevents the development of aortic hypertrophy by preventing hypertrophy of vascular smooth muscle cells (VSMC). In the losartan 0.75 group, these parameters were not changed. But in the losartan 15 and losartan 0.75 groups, the collagen content of the aortic media decreased significantly. CONCLUSION: It is inferred that the effect of Ang Ⅱ on stimulating VSMC growth of the aorta in SHR is dependent on arterial pressure, while the effect on collagen fibers is through pressure independent mechanism.
