Effect of calcitonin gene-related peptide (CGRP) on myocardial ischemic injury in rat
- VernacularTitle:降钙素基因相关肽对大鼠心肌缺血损伤的影响
- Author:
Jianxin TAN
;
Yansong LI
;
Yuge HUANG
;
Wenqing LU
;
Changrong LI
- Publication Type:Journal Article
- Keywords:
Calcitonin gene-related peptide;
Myocardium;
Ischemia;
Oxygen;
Free radicals;
Enzymes
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effects of intravenous (iv) CGRP on myocardial injury in rat. METHODS: Establish a rat myocardial ischemic injury model by subcutaneous injection of single dose of isoproterenol (ISO), and treat the model with single dose of iv CGRP. Two hours later, serum CK, LDH, MDA and SOD levels were measured, MDA and SOD in myocardial tissue were tested, and myocardial tissue structures were observed. RESULTS:(1) Serum MDA and tissue MDA levels increased significantly and serum SOD and tissue SOD decreased significantly in injury group, in the CGRP treated group, the above changes were reversed (P
