Changes of serum autoantibodies against ?_1 and M_2 receptors in the patients of obstructive sleep apnea syndrome with chronic obstructive pulmonary disease
- VernacularTitle:阻塞性睡眠呼吸暂停综合征合并慢性阻塞性肺病患者血清中?_1与M_2受体自身抗体的变化
- Author:
Manjing SONG
;
Pei WANG
;
Zhuola LIU
;
Juan FU
- Publication Type:Journal Article
- Keywords:
Sleep apnea syndroms;
Lung diseases, Obstructive;
Receptors, adrenergic,beta;
Receptors, cholinergic;
Autoantibodies
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the changes of serum autoantibodies against ? 1- adrenergic and M 2-muscarinic receptors in obstructive sleep apnea syndrome (OSAS) patients with chronic obstructive pulmonary disease (COPD), that is, overlap syndrome (OS). METHOD: Serum autoantibodies against ? 1 and M 2 receptors in 26 cases with OS, 32 with OSAS, 30 with COPD and 28 normal subjects were determined by using enzyme-linked immunosorbent assay(ELISA). RESULTS: The positive rates and titer of ? 1 and M 2 receptor autoantibodies are significantly increased in OS group (92.2%,57.7% and 1∶98, 1∶67), compared to OSAS (71.9%, 40.6% and 1∶83, 1∶30) or COPD group (70.0%, 36.7% and 1∶79, 1∶28) (P
