Effect of carbon monoxide on hypoxic proliferation of rat pulmonary arterial smooth muscle cell
- VernacularTitle:一氧化碳对大鼠血管平滑肌细胞低氧性增殖反应的作用
- Author:
Guansong WANG
;
Guisheng QIAN
;
Xiaojing YANG
;
Weizhong CHEN
- Publication Type:Journal Article
- Keywords:
Carbon monoxide;
Anoxia;
Muscle,smooth,vascular;
Growth
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore the effect of carbon monoxide (CO) on hypoxic proliferation of rat pulmonary arterial smooth muscle cell(PASMC). METHODS:Rats were randomly divided into four groups, including: (1)N:Normoxia group (21% O 2); (2)H:Hypoxia group (1% O 2); (3)CO+H:CO+hypoxia group (3% CO+1% O 2),tested by immunocytochemical analysis,[3H]-TdR incorporation and flow cytometry (FCM). RESULTS: (1)Flow cytometric DNA analysis revealed that hypoxia induced significantly enhancement of G 2/M phase and decreased G 0/G 1 phase of PASMC ( P
