Effect of basic fibroblast growth factor on radiation-induced splenocytic apoptosis of mice
- VernacularTitle:碱性成纤维细胞生长因子对小鼠脾脏细胞凋亡的抑制作用
- Author:
An HONG
;
Yanli XU
;
Xiaokun LI
;
Jian LIN
;
Shuzheng LIU
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor,basic;
Spleen;
Cells;
Mice
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of basic fibroblast growth factor (bFGF) on radiation-induced splenocytic apoptosis of mice. METHODS: At 14 h after whole body irradiation with 0.5 Gy and 1.0 Gy,splenocytes were cultured with and without bFGF,and splenocytic apoptosis was quantitatively analysed by flow cytometry. Cell proliferation was determined by the method of [3H]-TdR incorporation. RESULTS: bFGF(1 ?g/mL and 2 ?g/mL) could reduce the rate of cell apoptosis ,and promote the proliferation of splenocytes. CONCLUSION: bFGF could inhibit radiation-induced splenocytic apoptosis and promote the proliferation of splenocytes and then enhance body immunity.
