The effect of mifepristone on natural killer subsets of peripheral blood and decidua in early pregnancy
- VernacularTitle:米非司酮对早孕外周血和蜕膜组织自然杀伤细胞亚群的影响
- Author:
Qian HOU
;
Yaoying ZENG
;
Zineng WANG
- Publication Type:Journal Article
- Keywords:
Decidua;
Killer cells,natural;
Mifepristone;
Estrogens;
Progesterone
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of mifepristone on natural killer(NK) subpopulations of peripheral blood and decidua in early pregnancy. METHODS: Flow cytometry was used to detect the expression of CD56 and CD16 on lymphocytes of decidua and peripheral blood in early pregnancy, mifepristone-treated pregnancy. RESULTS: The percentages of different natural killer subsets in peripheral blood between early pregnancy and mifepristone-treated pregnancy were almost identical. The serum levels of estradiol and progesterone in mifepristone-treated pregnancy were slightly higher than in early pregnancy. The percentage of decidual CD56+NK cell in early pregnancy was significantly higher than in mifepristone-treated pregnancy. The CD56+NK cells were predominant lymphocyte population of decidua in mifepristone-treated pregnancy, but in which the CD56+CD16+ and CD16+NK cells were major lymphocyte subpopulations of peripheral blood. CONCLUSION: Mifepristone acted principally on feto-maternal interface, it blocked the proliferation and differentiation of decidual CD56+NK cells and induced embryo immune rejection.
