Effect of urapidil on the levels of four kinds of plasma neuropeptides in patients with hypertension
- VernacularTitle:乌拉地尔对高血压患者血浆4种神经肽含量的影响
- Author:
Min LIANG
;
Saijuan LIN
;
Ning LIANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Urapidil;
Endothelin;
Calcitonin gene-related peptide;
Neuropetide Y;
Neurotension
- From:
Chinese Journal of Anesthesiology
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of urapidil on the levels of 4 kinds of plasma neuropeptides : endothelin(ET),neuropetid Y(NPY),calcitonin gene-related peptide(CGRP) and neurotensin(NT) in patients with hypertension. Methods Twenty patients with hypertension ,scheduled for surgery,received urapidil 0.5mg/kg intravenously before anesthesia induction .The intravenous blood samples were taken before and 5min after the administration ,to measure the plasma levels of ET,NPY,CGRP and NT with radioimmunoassay . Twenty health humans served as control. Results Compared with control levels, ET and NPY levels increased markedly and CGRP and NT levels decreased significantly in the patients with hypertension (P
