Effect of lidocaine and bupivacaine on Na~+ current in the dorsal horn neurons of spinal cord
- VernacularTitle:利多卡因和布比卡因对鼠脊髓背角神经元钠通道电流的影响
- Author:
Baogang LIU
;
Xinliang ZHUANG
;
Guohui XU
- Publication Type:Journal Article
- Keywords:
Lidocaine;
Bupivacaine;
Dorsal horn neurons;
Na+ current
- From:
Chinese Journal of Anesthesiology
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The effect of lidocaine and bupivacaine on the Na+ current of dorsal horn neurons was observed to further evaluate the mechanism of local anesthetics . Methods The dorsal horn neurons of the SD neonates(0-7 d) were isolated acutely. Under the condition of holding voltage -80mV , and testing voltage -30mV with duration of 20 ms , the whole-cell patch-clamp technique was applied to recording the changes of voltage-gated Na+ currents following the administration of lidocaine or bupivacaine at 50-1000?mol/L.Results The voltage-gated Na+ currents ranged from 0.5-8nA peak amplitude , was inhibited by lidocaine and bupivacaine at clinical concentrations, the inhibitory degree was parallelly correlated with the concentration of local anesthetics(r=0.949 and 0.847 ,P
