Effect of altitude hypoxia on somatostatin and ?-aminobutyric acid content of rat hypothalamus
- VernacularTitle:高原低氧对大鼠下丘脑生长抑素和?-氨基丁酸含量的影响
- Author:
Huaizhen RUAN
;
Xiaotang FAN
;
Jinhai ZHANG
;
Bibo YUAN
;
Xigui WU
- Publication Type:Journal Article
- Keywords:
Altitude;
Anoxia;
Somatostatin;
RNA, messenger;
Aminobutyric acids
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the effect of altitude hypoxia on ?-aminobutyric (GABA) content and prepro-somatostatin mRNA (PPS-mRNA) in the rat hypothalamus. METHODS: Using altitude hypoxia model,in situ hybridization and amino acid analyzer, the number of PPS-mRNA and GABA content in rat hypothalamus was determined. RESULTS:After altitude hypoxia, the contents of GABA in hypothalamus and the number of PPS-mRNA neurons in periventricular nucleus (PeVN), paraventricular nucleus (PaVN) and arcuate nucleus (ArcN) increased significiantly. Bicuculline, a GABA receptor antagonits, could enhance PPS-mRNA expression evoked by altitude hypoxia, but had no effect on GABA content. CONCLUSION: Altitude hypoxia can induce neurotransmitter imbalance of hypothalamus.
