Effect of calcitonin gene-related peptide on proliferation of vascular smooth muscle cells
- VernacularTitle:降钙素基因相关肽对人血管平滑肌细胞增殖的抑制作用
- Author:
Xiaoyan LI
;
Congxin HUANG
;
Yougang SUN
;
Jinming WANG
;
Jing WANG
;
Teng WANG
- Publication Type:Journal Article
- Keywords:
Muscle, smooth, vascular;
Cells cycle;
Calcitonin gene related peptide
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To elucidate the effect of calcitonin gene-related peptide (CCRP) in the therapy of atherosclerosis.METHODS:Effect of CGRP on cell cycle kinetics of cultured vascular smooth muscle cells(HA-VSMC) was investigated by flow cytometry. The expression of cyclins D 1 and E required for initiation of S phase were also studied by immunochemistry method. RESULT: CGRP was shown to arrest VSMC in the G 0/G 1 phase of cell cycle and reduced expression of cyclins D 1 and E. CONCLUSION:CGRP inhibits proliferation of HA-VSMC by arresting cells in G 1 phase via limiting accumulation of cyclin D 1 and E. It might play a role in the therapy of atherosclerosis.
