Effects of endotoxin on phospholipid metabolism and membrane fluidity in liver mitochondria of goats
- VernacularTitle:内毒素对山羊肝线粒体膜磷脂代谢及膜流动性的影响
- Author:
Hong GAO
;
Liqin TAN
;
Weizhen LI
;
Zhaoxin TANG
;
Wanfan CHEN
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Membranes;
Phospholipids;
Membrane fluidity;
Mitochondria;
Erythrocyte membrane
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHOD:To study the changes of contents of phosphatidyl inositol (PtdIns),phosphatidylserine (Ptdser),phosphatidylethanolamine (PtdEtn) and phosphatidylcholine(PtdCho) in hepatic mitochondria membrane of goats in vivo at 5 h after administration of E. coli endotoxin(1800 U/kg body weight) with HPLC. The membrane fluidity of the erythrocyte and liver mitochondria of E. coli endotoxin treated group was examined with the fluorescence polarization technique, in which 1,6-diphenyl-1,3,5,-hexatriene was used as a fluorescence probe. RESULTS: E. coli endotoxin treated group (group II) led to a marked decrease of PtdIns, PtdSer, PtdEtn, PtdCho contents of hepatic mitochondria in vivo at 5 h as compare to the normal control (group I) ( P
