Hypertonic NaCl-NaAc improves the microcirculation in rats subjected to hemorrhagic shock
- VernacularTitle:高渗氯化钠-醋酸钠溶液改善失血性休克大鼠微循环的作用
- Author:
Xuewu ZHOU
;
Deyao HU
;
Liangming LIU
;
Kesen ZHAO
;
Xuliang HUANG
;
Zuojian ZHU
- Publication Type:Journal Article
- Keywords:
Saline solution, hypertonic;
Actic acids;
Shock, hemorrhagic;
Microcirculation
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of hypertonic NaCl-NaAc on microcirculation in hemorrhage-shocked rats.METHODS: SD rats were randomized into three groups of 7 5% NaCl(hypertonic saline, HS),5% NaCl-3 5% NaAc(hypertonic sodium acetate, HSA) and 0 9% NaCl(normal saline, NS) 4 mL/kg HS,HSA or NS was given intravenously following hemorrhagic shock The microcirculation of spinotrapezius muscle was observed RESULTS: HS increased mean aortic pressure more significant than HSA Variables including arteriolar and venular diameter,velocity and volumetric flow rate and open capillaries were increased and erythrocyte aggregation was decreased in 5 min after resuscitation with both HS and HSA solutions 5 min later,variables were deteriorated in HS group After local treatment, arteriolar and venular diameters were dilated significantly in HSA group CONCLUSION:HSA had superior effects to HS in improving microcirculation of hemorrhage-shocked rats
