Effects of Angelica Sinensis on OLDL-induced decrease of NO release from human endothelial cells and increase of ICAM-1 expression on the surface of human endothelial cells
- VernacularTitle:当归对氧化低密度脂蛋白致内皮细胞分泌一氧化氮下降和细胞间粘附分子-I表达升高的影响
- Author:
Xiaohong YAN
;
Jingping OUYANG
;
Shuzen TU
;
Shufang GUO
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
Oxides;
Lipoproteins,LDL;
Endothelium, vascular;
Nitric oxide;
Cell adhesion molecules;
Angelica Sinensis
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the injurious effects of oxidized low-density(OLDL) on human endothelial cells(ECs) and protective effects of Angelica Sinensis in vitro. METHODS: The effect of OLDL on nitric oxide (NO) release from EC and intercellular adhesion molecule-1 (ICAM-1) expression on EC surface were studied, and the protective effects of Angelica Sinensis on normal and abnormal EC were investigated using cultured EC with or without OLDL and immunocytochemical staining technique. RESULTS: OLDL led to a decrease of NO release and an increase of ICAM-1 expression, which can be reversed by Angelica Sinensis and atropine can block this role of Angelica Sinensis. CONCLUSION: Angelica Sinensis has antagonistic effect on OLDL-induced decreasing of NO released from ECs and increasing of ICAM-1 expression on ECs surface . These effects of Angelica Sinensis may be exerted by the excitation of muscarinic receptor.
