The effect of glucocorticoid receptor on level of inflammatory media in rats after critical scald
- VernacularTitle:糖皮质激素受体减少对严重烫伤大鼠体内炎症介质水平的影响
- Author:
Hai LIN
;
Sufang XIAO
;
Zhongqing LIN
;
Xueyi LIN
;
Yuna SONG
;
Xilin JIANG
- Publication Type:Journal Article
- Keywords:
Receptors, glucocorticoid;
Inflammation;
Syndrome;
Burns
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To further elaborate the effect of glucocorticoid receptor(GR) decrease on level of inflammatory media in rats after critical scald.METHOD:The changes of phospholipase A 2(PLA 2) activity and concentrations of tumor necrosis factor alpha (TNF?) and malondialdehyde (MDA), the product of lipid peroxidation metabolism in plasma and tissue homogenate have been studied in scalded rats with or without GR blockade by RU38486.RESULTS:The PLA 2 activity and the concentrations of TNF? and MDA in plasma and homogenate of pulmonary and renal tissue in scalded rats were significantly higher than those in the controls( P
