Effect of 2,3-butanedione monoxime (BDM) on myocardial protection in cold cardioplegia
- VernacularTitle:2,3-丁二酮单肟对冷停搏心脏的保护作用
- Author:
Jingping OUYANG
;
Yongming LIU
;
Hanqiao ZHENG
;
Lei WEI
;
Shuzhen TU
;
Hailu YANG
;
Yejia CUI
- Publication Type:Journal Article
- Keywords:
Heart arrest, induced;
Perfusion, regional;
Myocardial contraction;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: The effects of BDM on isolated rat heart in cold cardioplegia were studied METHODS: Rat heart were subjected to cold cardioplegia at 4℃ for 8, 18 and 24 h Then each heart was perfused (90 cm H 2O) in Langendorff model at 37℃ for 40 min In the high K + group( n =24) the hearts were preserved in St Thomas cardioplegic solution, in BDM group( n =24) hearts were preserved in K-H solution with BDM 30 mmoL/L RESULTS: After 18 h, heart rate and the coronary flow in BDM group were significantly higher than in high K + group( P
