The role of ATP-sensitive K~+ channels in the cardiovascular system
- VernacularTitle:ATP敏感钾通道在心血管系统中的作用
- Author:
Fanxue MENG
;
Xiaohui JIAO
;
Daying HAN
- Publication Type:Journal Article
- Keywords:
Potassium channels;
Cardiovascular system
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
years ago, Noma first applicated the patch\|clamp technique to CN\|treated mamammalian heart cells,evealed specific K + channels which were depressed by intracellular ATP at level greater than 1 mM.He suggested the ATP-sensitive channels are important for regulating cellular energy metabolism in the control of membrane exitability.Recent studies supported the hypothesis and suggested that ATP-sensitive channels play an important role in hypoxia,myocardial ischemia/reperfusion and is chemic preconditioning.
