Radioimmunoimaging of ~(99m)Tc labeled anti-mouse uterine cervical cancer monoclonal antibody Au_(14-1) in tumor-bearing mice
- VernacularTitle:~(99m)Tc标记单克隆抗体Au_(14-1)对荷宫颈癌小鼠的放射免疫显像研究
- Author:
Fangyun XU
;
Hongmei WANG
;
Shuyun WU
;
Gansheng WEN
;
Qiuru LIU
;
Wenhua GONG
;
Qing ZHANG
;
Liyue XIONG
- Publication Type:Journal Article
- Keywords:
Antibodies, monoclonal;
Cervix neoplasms;
Radioimmunoassay
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: A study of radioimmunoimaging was carried out on Kcnming mice - uterine cervical cancer (U14) using 99mTc labeled monoclonal Au14-1 with a modified Schwartaz method. RESULTS: The bio - distribution showed that radioactivity accumulated in tumor tissue at 12h after 99mTc - Au14- 1 injection in tail vein. The uptake by tumor was 4. 12 % ID/g at 2h and 8. 79 % ID/g at 24h respectively. The tumor/non - tumor (T/NT) radiocativity ratios for organs except kidneys were ranged from 2.02 to 6.71 at 24h post - injection. The image of tumor showed at 12h and clearer at 24h after injection. CONCLUSION: The quality of tumor image was relevant to the T/NT radioactivity ratios. It was demonstrated that 99mTc- Au14-1 has a good capability of localization for tumor.
