Change of calcimn metabolism in liver mitochondria and its effect on mitochondrial respiratory function fol- lowing biliary obstruction
- VernacularTitle:胆道梗阻后肝线粒体钙代谢变化及其对呼吸功能的影响
- Author:
Jing LI
;
Yanbang CHI
;
Xuejun FANG
- Publication Type:Journal Article
- Keywords:
Bile duct disease;
Mitochondria;
Liver;
Calcium
- From:
Chinese Journal of Hepatobiliary Surgery
1998;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of liver mitochondrial calcium metabolism and its effect on mitochondrial respiratory function.Methods The model of dog biliary obstruction was made by bile duct ligation. Mitochondria were obtained by differential centfifugation.Mitochondrial calcium content,calcium uptake rate and respiratory function were observed and compared.Results Liver mitochondrial calcium content was increased sig- nificantly,calcium uptake rate and respiratory function were obviously reduced after biliary obstruction.Mitochon- drial calcium content was highly negatively correlated with mitochondrial respiratory function (P
