Effect of salvia miltiorrhiza compound on production of endothelin and thromboxane in patients undergoing CPB
- VernacularTitle:复方丹参对体外循环患者血清内皮素和血栓素水平的影响
- Author:
Jiazhen GU
;
Zhengyuan XIA
;
Haibo HUANG
- Publication Type:Journal Article
- Keywords:
Salvia miltiorrhiza Endothelin Thromboxane Cardiopulmonary bypass
- From:
Chinese Journal of Anesthesiology
1995;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of salvia miltiorrhizae compound (SMC) on serum endothelin (ET), TXB_2 and PGI_2 levels in patients undergoing CPB. Method: Twenty patients with congenital heart disease were randomly divided into control group (group Ⅰ) and treated group (group Ⅱ). SMC (200mg/kg) were given intravenously in group Ⅱ before operation and during rewarming, in group Ⅰ eqivalent volumes of normal saline were administered at the same time point. The serum ET,TXB_2 and PGI_2 levels were measured at preoperation (T_0) 5min (T_1), and 30min (T_2) following CPB, 10min (T_3), 30min (T_4) and 60min (T_5) following reperfusion, 24h (T_6) after operation. Result: In both groups,the serum ET level were increased significantly during reperfusion, but much less in group Ⅱ than that in group Ⅰ at T_4, T_5 and T_6(P
