Action of pentoxifylline on oxygen free radicals-induced myocardial injury
- VernacularTitle:己酮可可碱对自由基致心肌损伤的保护作用及其机制
- Author:
Huifang XU
;
Li WANG
;
Wei JIANG
- Publication Type:Journal Article
- Keywords:
Myocardium Oxygen free radicals Pentoxifylline Superoxide dismutase Catalase Indomythacin
- From:
Chinese Journal of Anesthesiology
1995;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of pentoxifylline (PTX) on oxygen free radicals induced myocardial injury. Method: An in vivo myocardial impairment model was developed in SD rat with exogenous oxygen free radicals. The changes cardiac performance and serum malonylaldehyde (MDA), lactic acid, cretine phosphokinase (CK) levels were tested before and at different interval after I. V. administration of oxygen free redieal. Result: Myocardial performance after oxygen free radicals administration was significantly depressed compared to the baseline values (P
