Effects of propofol on myocardial ? adrenergic receptor in rats
- VernacularTitle:异丙酚对大鼠心肌?受体的影响
- Author:
Xiongqing HUANG
;
Bingxue CHEN
;
Hanping LU
- Publication Type:Journal Article
- Keywords:
Propofol Myocardium Receptors, adrenergic ?
- From:
Chinese Journal of Anesthesiology
1995;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of the bolus propofol on myocardial ? adrenergic receptor. Method: Twenty-one,aging 4-6 weeks,male health SD rats,were divided randomly into three groups:low dose group (L)with propofol of 5mg/kg,high dose group(H)with 12mg/kg of propofol and control group(C) with NS alone. The drugs were administered through the rat's tail vein in conscious state. 3 minutes after administration,the raps heart were totally taken out to investigate rat's myocardial ? adrenergic receptors with radioligand binding assay. Result:Compared with those in control group,in L group there was a decrease in ? adrenergic receptor density(Bmax),but no change in the affinity of ? adrenergic receptor (KD); In H group,Bmax decreased,KD value increased. The Bmax and KD were significantly different between L and H group. Conclusion:Intravenous bolus doses of propofol may cause down-regulation on myocardial ? adrenergic receptor of rats in dose-related way.
