Effects of naioxone for analepsia of general anesthesia on plasma concentrations of A Ⅱ , E, NE, ET and ANP
- VernacularTitle:纳洛酮用于全麻催醒时血浆AⅡ、E、NE、ET和ANP浓度的变化
- Author:
Yuping ZHANG
;
Jianjun CUI
;
Youliang YU
- Publication Type:Journal Article
- Keywords:
Naloxone;
Analeptics;
Anesthesia,general;
Catecholamine;
Angiotension Ⅱ;
Complications
- From:
Chinese Journal of Anesthesiology
1997;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the cause of complications after naloxone (Nal) for administration analepsia of general anesthesia. Method: Thirty-six cases were randomly divided into group Ⅰ (n=12, Nal 0.004mg?kg~(-1)), group Ⅱ (n=12,Na1 0.002mg?kg~(-1)) and group Ⅲ (n=12,NS). The dosage was administrated intravenously in a bolus at the end of operation. The venous blood samples were taken respectively before anesthesia (T_1),Smin before and after the administration (T_1 ,T_3) to measure the plasma concentration of E and NE with high performance liquid chromatography,and those of A Ⅱ, ET and ANP with radioimmunoassay. The complications after the administration were observed. Result: Compared with T_1 and T_2, the plasma concentrations of A Ⅱ, E and NE obviously increased at T_3 in group Ⅰ and group Ⅱ (P
