Application of mitomycin-C in reliving cancerous pain
- VernacularTitle:丝裂霉素在癌性疼痛治疗中的应用
- Author:
Jianxun HE
;
Meihua WANG
- Publication Type:Journal Article
- Keywords:
MitomycinC;
Neoplasms;
Analgesia;
Pathology,Clinical
- From:
Chinese Journal of Anesthesiology
1997;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of reliving cancerous pain with mitomycin C(MMC). Method:Sixteen patients with terminal cancerous pain received epidural, sacral or neuroplexus administration of MMC 4-8mg (concentration:1-2mg/ml) once a day or every other day, lasting 3-4times and degree of pain relief was evaluated. In different concentration solutions of MMC and normal saline, the pathologic changes of separated nerve of live body in sharp dissection, immersed for 1-24hours (37℃), was observed under microscope. Result: All patients got a good pain relief for 2-6 weeks, nine of them did not required any narcotic analgesic, the other cases needed analgesics, but the dosage required was reduced by 1/2-1/3 and adverse effects did not occur. Pathologic results showed that nerve fiber atrophy appeared with range disturbance, neurilemma changes were dominated by fatty degeneration. Conclusion: MMC can relive cancerous pain,through producing fatty degeneration of neurilemma to reduce excitatory transmission and alleviating nervous constriction of tumor.
