Naloxone reversal of cerebral ischemic injury following cardiac arrest
- VernacularTitle:纳洛酮对犬心脏骤停后缺血性脑损害的复苏作用
- Author:
Hong GAO
;
Yuwen AN
;
Kaiyun FANG
- Publication Type:Journal Article
- Keywords:
Naloxone;
Cardiac arrest;
Cerebral ischemic injury;
Cerebral resuscitation
- From:
Chinese Journal of Anesthesiology
1997;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine if naloxone has reverse effect on cerebral ischemic injury following cardiac arrest. Method:Ten dogs underwent 15-min cardiac arrest and then were divided into two groups during 3-hour cardiopulmonary resuscitation (CPR). Group A(n=5): the animals were administered with conventional CPR;group B(n=5): in addition,at onset of CPR,an I. V. bolus of 0.2mg?kg~(-1) of naloxone,followed by infusion of 0.02mg?kg~(-1)?h~(-1). Result: Cerebral blood flow, Cerebral perfusion pressure in group B were significantly higher than those in group A (P
