Changes of plasma histamine concentration and hemodynamics following divided-doses mivacurium administration for intubation in surgical patients
- VernacularTitle:插管剂量美维松分次注射时血组胺及血液动力学的变化
- Author:
Junke WANG
;
Yang NAN
;
Zhuoren SHENG
- Publication Type:Journal Article
- Keywords:
Mivaeurium Atraeurium Histamine Hemodynamics
- From:
Chinese Journal of Anesthesiology
1995;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of divided-doses mivacurium on histamine releasing and hemodynamics. Method: Forty-two patients were randomly divided into seven groups (n=6, each group). The total dose of 3?ED_(95)(0.25mg/kg)mivacurium for intubation was injected intravenously in single-dose in group I, or in divided-doses of 0.05+0.2mg/kg, 0.10+0.15mg/kg, 0.125+0.125mg/kg, 0.15+0.1mg/kg, and 0.2+0.05mg/kg in group Ⅱ, Ⅲ,Ⅳ, Ⅴ and Ⅵ respectively, and 0.6mg/kg of atracurium bolus in group Ⅶ, The plasma histamine concentration and systolic blood pressure(SP), diastolic blood pressure(DP) and heart rate(HR) were determined before and 3, 5, 10, and 15 min after injection of mivacurium or atracurium. Result: The plasma histamine concentration and changes of SP, DP, HR were decreased in group Ⅳ compared with those in other groups. Conclusion: The divided dose of 3?ED_(95) mivacurium for intubation may reduce histamine release and changes in hemodynamics.
