Effeets of ProPofol on left ventrieular funetion of aeute myoeardial isehemia-reperfusion injury in canines
- VernacularTitle:异丙酚对犬急性心肌缺血再灌注损伤左心室功能的影响
- Author:
Keming ZHU
;
Xiaoming DENG
;
Meiying XU
- Publication Type:Journal Article
- Keywords:
Propofol Myoeardial reperfusion iniury Left ventrieular function
- From:
Chinese Journal of Anesthesiology
1995;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
objective:To evaluate the effeets of Propofol on left ventrieular funetion of aeute myoeardial isehemia-reperfusion injury in eane.Method:Eighteen hybrid dogs(11一14kg)were divided randomly inro three groups:NSgroup(norrnal saline,Zml?kg一l?h一1),HP group(high一dose propofol,11.Zmg?kg一1?h一1),LP group(low一dosepropofol,5.6mg?kg一'?h一').These dogs were subjeeted to a 90一min left anterior deseending eoronary artery oeelu-5 ion followed by 200min of rePerfusion.Before ad而nistrat一on,60min after administration,at oeelusion一90min and60min.12Ornin and180min壬ollowing reperfusion left ventrieular funetion was assessed by measurement of LVSP,LVEDP,dp/dtmax and dP/dtmin.Result:Compared with the baselines,LVSP,dp/dtmax and dP/dtmin 60 min afteradrninistration deereased byg%,17%and 17%respeetively,LVEDP inereased by 80%in HP grouP.120min and180min during reperfusion LVSP.dp/dtmaxanddp/dtmininHPandLPgroupweresignifiea八tlyhigherthanthoseinNs group。.05),LvEDP signifieantly lower than that in NS group(p
