Influence of ?-hydroxybutyric sodium on the pharmacokinetics of ketamine infusion in preschool children
- VernacularTitle:羟丁酸钠对学龄前儿童静脉滴注氯胺酮药代动力学的影响
- Author:
Ping ZHAO
;
Lianzhi NIE
;
Li WANG
- Publication Type:Journal Article
- Keywords:
Ketamine Sodium oxybate Pharmacokinetics Child,preschool
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To determine the influence of ?-hydroxybutyric sodium (7-OH)on the pharmacokinetics of ketamine infusion in preschool children. Method: Sixteen patients were randomly assigned to group Ⅱ (Ketamine) and group Ⅱ (Ketamine plus ?-OH). After trachea intubation,0.05% ketamine was infused in both groups at 3mg?kg~(-1)?h~(-1) and ?-OH 125mg?kg~(-1) only in group Ⅱ. The plasma concentration of ketamine was measured using high performance liquid chromatography. Pharmacokinetic parameters were calculated using 3P_(87) software composed by Chinese Pharmacologic Society. Result: In both groups,pharmaeokinetics could be descrided as two-compartment open model. The T_(1/2)? and the Cl differ between group Ⅰ and group Ⅱ (P
