Behamioral Change and Memory Inpairment Following Transient Forebrain Ischemia in Rats .
10.4097/kjae.1991.24.5.925
- Author:
Choon Kook RHO
1
;
Jae Young KWON
;
Hae Kyu KIM
;
Seong Wan BAIK
;
Inn Se KIM
;
Kyoo Sub CHUNG
Author Information
1. Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Transient forebrain ischemia;
Open field test
- MeSH:
Animals;
Carotid Artery, Common;
Grooming;
Hippocampus;
Humans;
Hypotension;
Ischemia*;
Male;
Memory*;
Motor Activity;
Neurons;
Prosencephalon*;
Rats*
- From:Korean Journal of Anesthesiology
1991;24(5):925-930
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study examined the behavioral change and memory impairment following transient forebrain ischemia in 20 male rats: ten rats were subjected to sham operation. Inchemia was induced by a combination of bilateral common carotid artery occlusion and induced hypotension. During the recovery period, behavioral change was evaluated by open-field method. Histopathological examination was performed 7 days after ischemic insult. The results were as follows 1) Hippocampus CA 1 neuron was the most vulnerable to 10-minute forebrain ischemia. 2) There was increase in locomotor activity and rearing during early post-ischemic period. 3) Ischemia resulted in suppressed preening and grooming. From the above mentioned results, authors suggested that transient forebrain ischemia produced severe neuronal damage in CA l sector of hippocampus, therefore produced behavioral change and memory impairment.
