Effects of propofol on coronary circulation of acute myocardial ischemia-reperfusion injury in canines
- VernacularTitle:异丙酚对犬急性心肌缺血再灌注损伤冠脉循环的影响
- Author:
Keming ZHU
;
Xiaoming DENG
;
Meiying XU
- Publication Type:Journal Article
- Keywords:
Propofol Myocardial reperfusion injury Coronary circulation
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the effect of propofol on coronary circulation of acute myocardial ischemia-reperfusion inury. Metbod: 18 hybrid dogs (11-14kg) were divided randomly into three groups:NS group (normal saline, 2ml?kg~(-1)?h~(-1)), HP group (high-dose propofol, 11.2mg?kg~(-1)?h~(-1)), LP group (low-dose propofol, 5.6mg?kg~(-1) ?b~(-1)). These dogs were subjected to 90 min left anterior descending coronary artery (LAD) occlusions followed by 200 min of reperfusions. Before administration, 60 min after administration, 60min, 120min, 180min following reperfusion,coronary circulation was assessed by measurement of coronary perfusion pressure (CPP) and blood flow of LAD. Result: The values of CPP in HP and LP groups 60 minafter administration were significantly lower than those in NS group before LAD occlusion (P
