T Cell Chemotactic Response in Patients with Primary and Metastatic Malignant Melanoma
- VernacularTitle:恶性黑素瘤患者T细胞化学趋化功能
- Author:
Min ZHENG
;
Guojun SUN
;
Suiqing CAI
- Publication Type:Journal Article
- Keywords:
Melanoma T Lymphocytes Chemotaxis
- From:
Chinese Journal of Dermatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To address the question whether circulating T cells from the patients with primary and metastatic malignant melanoma show altered chemotaxis to monocyte chemotactic protein 1 (MCP 1) and its relation to tumor infiltrating lymphocyte (TIL) and metastasis. Methods Chemotactic responsiveness of T cells towards MCP 1 and immuno histochemistry study were investigated in patients with primary and metastatic melanoma compared to patients with basal cell carcinoma and healthy persons. Results T cells from primary and metastatic melanoma patients showed a significantly decreased chemotactic migration towards MCP 1 and that T cells from patients with basal cell carcinoma showed normal chemotactic response. Immuno histochemistry study showed that there was no correlation between the density of TIL and the decreased chemotaxis of circulating T cells to MCP 1 in patients with primary melanoma. Conclusion Circulating T cells from patients with primary and metastatic malignant melanoma show a MCP 1 specific decrease in chemotactic migration, this may be due to abnormal expression or modulation of MCP 1 receptor on these cells.
