The effect of delayed treatment with anti-TNF monoclonal antibody on systemic hemodynamics and multiple organ dysfunction in rats following prolonged hemorrhagic shock an resuscitation
- VernacularTitle:延迟应用TNF-?单抗治疗重度失血性休克的实验研究
- Author:
Yongming YAO
;
Jinsong CHEN
;
Yan YU
- Publication Type:Journal Article
- Keywords:
Shock, hemorrhagic Antibody, monoclonal Tumor necrosis factor Gene expression Hemodynamics Multiple organ failure
- From:
Chinese Journal of Anesthesiology
1996;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the effect of delayed treatment with monoclonal antibody to tumor necrosis factor-alpha (TNF-? MAb) on systemic hemodynamics and multiple organ dysfunction following prolonged hemorrhagic shock and resuscitation. Method: Adult male Sprague-Dawley rats were subjected to prolonged hemorrhagic shock (MAP of 4.00-4.66 kPa for 180 rain)followed by resuscitation over 50 min. The animals were treated intravenously with either TNF-? MAb (20.0 mg/kg) or the control protein(albumin,20.0 mg/kg)15 rain after the end of resuscitation(65 min after shock). Result: Compared to the albumin controls, delayed treatment with TNF-? MAh significantly reduced the total peripheral resistance index (P
