Effects of isoflurane,propofol and mild hypothermia on glutamate releases evoked by chemical anoxia in hippocampus brain slices of rats
- VernacularTitle:亚低温、异丙酚与异氟烷对缺氧大鼠海马脑片谷氨酸释放的影响
- Author:
Xinli SHAO
;
Enzhen WANG
;
Zhongcheng WANG
- Publication Type:Journal Article
- Keywords:
Isoflurane Propofol Hypothermia Anoxia Hippocampus Glutamate
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine whether mild hypothermia,isoflurane and propofol reduce gultamate release in rat hippocampus brain slices after hypoxia. Method: Brain slices preparations were separated and incubated from rat hippocampus. Glutamate released from rat brain slices during chemical anoxia(100?M KCN)were measured with a fluorescence assay,at 28℃,31℃ and 37℃ after anoxia and after administration of 1 MAC of isoflurane and 200 ?m propofol respectively. Result: Glutamate release was significantly reduced at 28℃ or 31℃ compare with that at 37℃ (P
