Effects of clonidine on releases of enkephalin and substance P from periaqueductal gray
- VernacularTitle:可乐定对中脑导水管周围灰质脑啡肽和P物质释放的影响
- Author:
Hongbing WANG
;
Shiao JIN
;
Liqiang RU
- Publication Type:Journal Article
- Keywords:
Clonidine Enkephalin Periaqueductal gray
- From:
Chinese Journal of Anesthesiology
1996;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The stimulative effects of clonidine on release of enkephalin and substance P from periaqueductal gray was studied to analyse the analgesic neurotransmitters related to alpha 2 adrenoceptor activation. Method: Twenty SD rats were allocated in pairs to receiving intraperitoneal clonidine 40?g in clonidine group or normal saline in control group. Immunohistochemical technique was used to measure the contents of enkephalin and substance P in slice of rat midbrain. Result:The immunoreaction of enkephalin from slice of rat midbrain was decreased significantly in clonidine group compared with control group(P
