The effects of propofol on myocardial contractility in rat vivo
- VernacularTitle:异丙酚对大鼠心肌收缩力的影响
- Author:
Yansheng ZHANG
;
Duoyou WANG
- Publication Type:Journal Article
- Keywords:
Propofol Myocardial contractility Thiopental
- From:
Chinese Journal of Anesthesiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
To determine the effect of propofol on myocardial contractility. Method: Twenty hamsters were allocated to receiving intravenous propofol 2.5mg?kg~(-1)(group Ⅰ) or thiopentone 4mg?kg~(-1)as control (group Ⅱ) dp/dt_(max), was determined using a catheter inserted into the left ventricle from right carotid artery. LVP (LVSP, LVDP, LVMP), CVP, HR were recorded simutaneously. Resutt: dp/dt_(max), decreased insignitieantly in group Ⅰ but signitieantly in group Ⅱ. LVP(LVSP, LVDP, LVMP) decreased, while CVP increased significantly in both groups (P0.05). Conclusion.. The influence of propofol on myocardial contractility is weaker than that of thiopenone.
