Effects of propofoi on Ca~(2+)-ATPase activity in rat cerebral synaptie membrane in vivo
- VernacularTitle:异丙酚对大鼠不同脑区突触体质膜Ca~(2+)-ATP酶活性的影响
- Author:
Jun WANG
;
Xingguo HU
;
Yinming ZENG
- Publication Type:Journal Article
- Keywords:
Propofol Synaptosomes Calcium ATPasc
- From:
Chinese Journal of Anesthesiology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Tn investigate the effects of propofol on Ca~(2+) ATPase activity in rat cerebral synaptic membrane. Method: Thirty SD rats were divided randomly into three groups. The aminals were administtered introperi toneally(ip) propofol 50mg?kg~(-1), 100mg?kg~(-1) or normal saline 10mg?kg~(-1)(control group), respectively. These rats were immediately decapitated after having disappeared righting reflex. In oredr to prepare synaptosomes, brain tissues were dissected on ice, then homogenized and centrifuged. Ca~(2+)-ATPase activity was assaed with spcetrophotometric analysis. Result: Propofol 100mg?kg~(-1) ip significantly inhibited Ca~(2+)-ATPase activity of cerebrocortical, brain stems and hippocampal synaptic membrane as compared with that of normal saline group(P
