Clinical Feature and Glycoprotein D Gene Sequence Analysis of a Wild Strain of HSV-2 Isolated from One Relapsed Patient with Genital Herpes
- VernacularTitle:一例复发性生殖器疱疹的临床及其致病的HSV2野生株的糖蛋白D基因序列分析
- Author:
Huilan YANG
;
Yuangxing LIAO
;
Ming LI
- Publication Type:Journal Article
- Keywords:
Herpes simplex virus 2 Glycoprotein D Polymerase chain reaction Sequence analysis
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relation between the clinical feature and glycoprotein D gene sequence analysis of a wild strain of HSV 2 isolated from one relapsed patient with genital herpes. Methods The partial glycoprotein D gene sequence of the above mentioned strain was amplified and cloned with PCR. Results The comparison of the amino acid sequence of gD gene between the wild strain and HSV 2G strain published showed that there was a mutation at site80 and site159. Conclusion In order to develop effective vaccine which is suitable for China, it is necessary to investigate the differences of the gene structure and function of gD among HSV isolated from China and other countries.
