The protective effect of coenzyme Q_10 on red blood cell membrane and its immunity in patient during extracorporeal circulation
- VernacularTitle:辅酶Q_10对体外循环中红细胞膜及免疫功能的保护作用
- Author:
Daming GOU
;
Zhihao YU
;
Yaping FENG
- Publication Type:Journal Article
- Keywords:
Coenzyme Q_10;
Cardiopulmonary bypass;
Erythrocytes;
Cell membrane;
Immunity
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the protective effect of coenzyme Q_10 on red blood cell membrane and its immunity in patient during extracorporeal circulation. Method: Twenty patients under extracorporeal circulation about 30 minutes were randomly divided into control group and coenzyme Q_10 group (n=10). Coenzyme Q_10 2mg/kg was added to the priming fluid in coenzyme Q_10 group. Plasma levels of malondialdehyde (MDA), free hemoglobin (FHb), immune adhe sion ability and immune compound of red blood cell membrane were measured before extracorporeal circulation, 15 and 30 minutes after beginning of cardiopulmonary bypass, and on first day morning after operation. Result; All different periods after beginning of cardiopulmonary bypass in coenzyme Q_10, group, MDA and FHb levels were lower and im mune adhesion ability was higher than those of control group. Conclusion: Coenzyme Q_10 may protect red blood cell membrane and its immunity of patient during extracorporeal circulation.
