The effects of inducible nitric oxide synthase(iNOS)inhibitor on the microcirculation of the rabbits mesenterium in septic shock
- VernacularTitle:诱导性一氧化氮合酶抑制药对感染性休克兔肠系膜微循环的影响
- Author:
Bingbing SONG
;
Junke WANG
;
Zhuoren SHENG
- Publication Type:Journal Article
- Keywords:
Microcirculation;
Shock;
septic;
Aminoguanidine
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of AG, an iNOS inhibitor on microcirculation of the septic shock rabbits. Method: The white rabbits were infused endotoxin(LPS, 300?g. kg~(-1)in lh. Two hours after the MAP de creased to 60% of the baseline, the rabbits were grouped randomly as L-NAME(n=6.30 mg. kg~(-1))I. V. group and AG(n=6,20 mg. kg~(-1)) I. V. group. Result: Two hours after MAP decreased, the blood velocity decreased, the arterio lar of mesenterium dilated by 18%(P
