Changes of oxygen metabolism and neutrophil cellular rheological characteristics in canine with respiratory distress syndrom induced with oleic acid
- VernacularTitle:油酸诱导犬呼吸窘迫综合征时氧代谢和中性粒细胞流变学特性的变化
- Author:
Changming WANG
;
Zhenxiang ZHANG
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome Oxygen Metabolism Neutrophils Rheology
- From:
Chinese Journal of Anesthesiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the alterations of oxygen delivery/consumpation, the deformability and adherence of neutrophil in canine with respiratory distress syndrom(RDS), Method:The 15 selected healthy mongrel dogs were randomly allocated to receiving intravenous oleic acid 0.06 ml. kg~(-1) (test group, n= 8)or equivalent volume of saline (control group, n=7) respectively following anesthesia induction. The hemodynamics was monitored with Swan-Ganz catheter technique, the neutrophils were collected from arterial blood with centrifugal way to measure the deformability and adherence at 1st, 2nd, 4th and 6th hour after the administration of oleic acid separately. The pulmonary pathological examination underwent at 6th hour after the administration. Result: The pathological findings of test group were compatible with the RDS pathological characteristics. One hour after the administration, the deformability decreased significantly and the adheranee increased markedly (P
