The effect of anti-TNF? monoclonal antibody on systemic hemodynamics in rats fallowing intestinal ischemia/reperfusion
- VernacularTitle:抗?TNF?单抗对肠缺血/再灌注大鼠血液动力学的影响
- Author:
Yongming YAO
;
Ye WU
;
Yan YU
- Publication Type:Journal Article
- Keywords:
Intestines Reperfusion injury Antibody, monoclonal Tumor necrosis factor Hemodynamics
- From:
Chinese Journal of Anesthesiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effect and its potential mechanism of monoclonal antibody to tumor necrosis factor-alpha(TNF? MoAb)on systemic hemodynamics and survival rate after intestinal ischemia/reperfusion (Ⅱ/R). Method: SD rats were subjected to 75 rain of superior mesenteric artery occlusion followed by 6 hours of reperfusion. The animals were treated intravenously with either TNF? MoAb(20mg/kg)or the control protein(albumin, 20mg/kg) 30 min prior to the onset of ischemia. Result: Pretreatment with TNF? MoAb significantly attenuated the decrease in blood pressure and cardiac index compared to controls throughout the 6-hour period of observation(P
