Effects of ketamine on nitric oxide/cyclic guanosine 3',5'-monophosphate signaling pathway in the rat brain in vivo
- VernacularTitle:氯胺酮对大鼠脑NO/cGMP信号转导系统的影响
- Author:
Xingguo HU
;
Jun WANG
;
Yinming ZENG
- Publication Type:Journal Article
- Keywords:
Ketamine Brain Nitrc oxide Cyclic GMP
- From:
Chinese Journal of Anesthesiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the effects of ketamine on nitric oxide synathase(NOS)activity, nitrc oxide (NO) output and cyclic guanosine 3', 5'-monophosphate(cGMP)content in the rat brain. Method: Thirty two SD rats were divided randomly into control group and ketamine group. The aminals were administred intraperitoneally(ip)normal saline 10mg?kg~(-1) or ketamine 100mg?kg~(-1), respectively. NOS activity and NO output were assassed with spectrophotometric analysis, cGMP content was measured with radioimmunoassay, Result: Ketamine 100mg?kg~(-1) ip significantly inhibited NOS activity(P
